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首页 固态药物研究 固态表征 无定型固态分散体的表征
 
 

 

无定型固态分散体的表征

水难溶性药物越来越多，这给传统的制剂带来了很大挑战。一个解决方案是把原料药和高聚物做成无定形固体分散剂，这样可以提高溶解度并防止原料药无定形重结晶。为了充分实现无定形分散剂的功效，原料药和高聚物需要达到分子水平的均匀混合，如果发生原料药和高聚物的相分离将导致溶解度降低及提高无定形重结晶的可能。晶云在表征无定形固体分散剂方面有独到之处，除了利用DSC和AFM, 我们还利用ssNMR来研究无定形固体分散剂。 请参阅下面发表在《美国药物综述》的一篇文章。

 

Click below to read our white paper "Characterization of Amorphous Solid Dispersions: One of Many Integrated Solid State Solutions Provided by Crystal Pharmatech" published on American Pharmaceutical Reviews:

http://www.americanpharmaceuticalreview.com/ViewArticle.aspx?ContentID=6218

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