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Improving Bioavailability of Poorly Soluble Drugs: A Complete Guide

1. The Challenge: Solubility and Bioavailability in Drug DevelopmentPoor aqueous solubility is one of the leading causes of failure in oral drug development. Approximately 40% of marketed drugs and up...

08 May 2026

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Why Strong In Vitro Supersaturation Does Not Always Improve Oral Exposure

What the dissolution curve does not show: the mechanisms that determine whether a supersaturating formulation actually delivers oral exposure for poorly soluble drugs. What Supersaturation Ratio Alone...

29 Apr 2026

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What Is Amorphous Solid Dispersion (ASD)? Benefits, Applications, and When to Use It in Drug Development

IntroductionPoor aqueous solubility is one of the leading causes of failure in oral drug development. In fact, ~40% of marketed drugs and up to 70–90% of pipeline compounds exhibit poor water solubil...

28 Apr 2026

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Solubility Enhancement Strategies for BCS Class II and IV Drugs: Which Levers Actually Change Developability

A practical framework for comparing amorphous dispersions, nanocrystals, lipid systems, salts, and co-crystals based on how each approach changes the development profile for poorly soluble oral drugs.

14 Apr 2026

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Developing Controlled Substances in CMC: Where Solid Form, Containment, and Supply Planning Intersect

This blog examines controlled-substance development from a CMC perspective, with emphasis on how solid form, containment, and supply assumptions can begin interacting earlier than many teams expect. F...

08 Apr 2026

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Solubility vs. Supersaturation: Why Apparent Solubility Can Mislead Your Development Decisions

This practical CMC guide explains how apparent solubility, true thermodynamic solubility, and supersaturation differ, and why that distinction matters for solid form selection, dissolution method design, and formulation strategy.

02 Apr 2026

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Predicting Solid-Form Change Under Real-World Humidity and Temperature Conditions

This practical CMC guide shows how humidity and temperature together affect solid forms, influence stability and manufacturability, and support better study design, control strategies, and packaging decisions

26 Mar 2026

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Mini-Tablet, Major Impact: From Lab to Commercial Scale

Crystal Pharmatech’s integrated mini-tablet platform accelerates development from lab to commercial scale. We provide precision engineering, 505(b)(2) expertise, and high-precision filling for APIs.

25 Mar 2026

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Short Half-Life vs. Once-a-Day Dosing: Breaking the Barrier

A short half-life doesn't rule out QD dosing. By leveraging Modified Release (MR) to flatten PK curves and addressing pillars like absorption windows and solubility, developers can bridge the gap from IR to once-daily regimens, ensuring patient compliance and therapeutic differentiation.

18 Mar 2026

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The Race to FIH: How Fast Can You Reach the Clinic?

We want to move fast to first-in-human. How quickly can formulation and clinical supply be ready for IND?In the high-stakes world of drug development, speed is the ultimate currency. But as the saying...

12 Mar 2026

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Peptide Crystallization Process Development: A Practical CMC Guide for Peptide APIs

Peptide crystallization process development can transform peptide API stability, filtration, and downstream manufacturability. Learn high-throughput screening, salt and polymorph screening, seeding, a...

11 Mar 2026

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Conquering the “Uncrystallizable”: Advanced Strategies for PROTAC Solid-Form Development

In the world of drug development, PROTACs (Proteolysis Targeting Chimeras) are notoriously difficult to crystallize. Their high molecular weight, inherent flexibility, and complex surface area often l...

10 Mar 2026

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Blog

The “Double-Limited” Challenge: Is ASD Always the Answer?

When a compound is both solubility and permeability limited, the reflex is often to reach for ASD. But is that always the right move? We walk through the systematic framework our team uses to find the true bottleneck.

05 Mar 2026

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