Early development form screens can be performed for a variety of reasons depending on the issues that are found during early development. We understand that different screens should be applied to different situations and we work with you to choose the best screen based on the issues that need to be resolved with your compound. For many compounds, low aqueous solubility can be a major challenge for oral dosage forms or other drug delivery routes. In these cases a salt, cocrystal or amorphous dispersion screen may be the best option. Other challenges can include hygroscopicity, chemical/physical stability, or melting point which may lead to a polymorph screen targeting a different crystalline form that may provide the solution. For early polymorph screens we use crystallization techniques that will favor the thermodynamically stable form to minimize form changes during storage and processing. Smaller abbreviated screens may be applicable at this stage to get initial information while there are still questions about the compound. We will provide options and risk assessments to help you understand the best way to move forward with selecting a form early in development.