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Crystal Bio Overview

Build from the established Crystal Pharmatech with experienced experts and advanced techniques to focus on analytical and bioanalytical analysis of biologics in CMC development with further extension to support pre-clinical and clinical sample analysis. 


Crystal Pharmatech - Dr.Alex Chen as CEO, focused on crystal form and formulation of small molecule drugs initially with a group of Merck scientists and further established to a global company ~ 250 employees with 3 R&D sites in Suzhou (China), New Jersey (USA), and Toronto (Canada).


Crystal Bio - Together with Dr. Shiaw-Lin(Billy) Wu as co-founder and CSO, a formal executive of BioAnalytix; Professor in Chemistry, Barnett Institute; Genetech; ThermoFisher, with more than 3 decades of experience in characterization of complex biologics with various advanced analytical techniques including analysis of proteins in various cells, tissues, blood, and related PK/PD studies using unique sample preparation techniques combined with hybrid mass spectrometry; further applied these approaches with regulatory strategies for multiple pharmaceutical companies in the US and abroad, ~ 80 scientific papers published in these areas.

Crystal Bio Overview

Crystal Bio Service Area

  • Typical CMC-related analysis of primary and higher order structure, product and process purity, and forced degradation with correlation bioactivity with MS identity for potential critical quality attributes. 


  • Additional modalities such as traditional types of ADC & novel conjugated combinations, mRNA & lipid nanoparticle in combination with a strategic partner.


  • Sample pretreatment strategy combined with LC-MS to complement assays used in various bioassays and cell/ gene analysis to support structure/ function elucidation. Analysis of protein expression from cell, tissue, or blood matrix. 


  • Bioactivity, effector functional (ADCC& ADCP), and ligand binding analysis for potency and mechanism of action.


  • PK/PD for investigational & preclinical analysis, and extendable to clinical analysis as needed.

Crystal Bio Analytical Techniques

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High-resolution Orbitrap Mass Spectrometer with various types of liquid chromatography and capillary electrophoresis.
High-resolution Orbitrap Mass Spectrometer with various types of liquid chromatography and capillary electrophoresis.
Various biophysical tools including FT-IR, nano-DSC, Intrinsic Fluorescence, and accessible MALLS, AUC, CD, DLS, and proton NMR.
Various biophysical tools including FT-IR, nano-DSC, Intrinsic Fluorescence, and accessible MALLS, AUC, CD, DLS, and proton NMR.
Cells (incubator), cryopreservation, ELISA (multi-mode plate reader with various absorption/ luminescence/ fluorescence), various cell-based assays, and accessible Flow Cytometer and PCR instruments.
Cells (incubator), cryopreservation, ELISA (multi-mode plate reader with various absorption/ luminescence/ fluorescence), various cell-based assays, and accessible Flow Cytometer and PCR instruments.
Details of instrument list upon request.
Details of instrument list upon request.
Contact Us
Address:
2005 Eastpark Blvd, Cranbury, New Jersey 08512, USA

Want to Know More?

If you have any questions, we will always be happy to help. Feel free to contact us by telephone, mail or leave a message.
Contact Us
bd_global@crystalpharmatech.com +1-609-604-8303
U.S
Suite 500-B, 3000 Eastpark Blvd, Cranbury, New Jersey 08512, USA
Canada
6800 Kitimat Rd, Unit 1, Mississauga, Ontario, Canada L5N 5M1
China
Suite B4-101, Biobay, 218 Xinghu Street, Suzhou Industrial Park, Suzhou, China, 215123
Suite 500-B, 3000 Eastpark Blvd, Cranbury, New Jersey 08512, USA
bd_global@crystalpharmatech.com +1-609-604-8303