Solid-State NMR (ssNMR) Analysis

Unambiguous Structural Characterization for APIs and Drug Products

Solid-state NMR (ssNMR) spectroscopy enables detailed structural characterization of APIs and drug products in the solid phase, providing critical insights into molecular structure, intermolecular interactions, and solid-form behavior that are not accessible through solution-based techniques.

Core ssNMR Characterization Capabilities

Solid-state NMR analysis provides direct insight into the structural and physicochemical properties of pharmaceutical solids, supporting identification and differentiation of:

Polymorphs and solid-state forms

Salt forms and counterion interactions

Solvates and hydrates

Amorphous and crystalline dispersions

Advanced ssNMR Analytical Techniques

A comprehensive suite of multidimensional and relaxation-based ssNMR techniques enables detailed structural and dynamic characterization of solid-state systems:

1D NMR (Line Shape Analysis)

Evaluates local chemical environments and detects structural heterogeneity, including polymorphic transitions and amorphous content.

2D NMR (Correlation Spectroscopy)

Reveals molecular connectivity and intermolecular interactions within and across crystal lattices, supporting detailed structural assignment.

Relaxation Measurements (T1/T2)

Quantifies molecular mobility and dynamics, enabling characterization of APIs, intermediates, drug products, and excipients in different solid states.

Versatile Nuclei Targeting for Solid-State Analysis

Advanced ssNMR techniques enable high-resolution analysis across multiple nuclei, providing comprehensive structural insights:

MAS and High-Power Decoupling (CP-MAS): Enhances spectral resolution and simplifies complex solid-state spectra for accurate interpretation.
Fluorine (¹⁹F) NMR: Highly sensitive detection for fluorinated compounds, enabling differentiation of polymorphs and amorphous phases.
Phosphorus (³¹P) NMR: Specialized applications for phosphorus-containing compounds and solid-state formulations.

Efficient Sample Utilization & High Sensitivity

Solid-state NMR supports quantitative and high-sensitivity analysis across a wide range of sample conditions:

Reliable results achieved with sample quantities ranging from milligrams to low hundreds of milligrams
Flexible optimization of limits of detection (LOD) and quantification (LOQ) based on sample characteristics
Enhanced signal-to-noise ratios through advanced acquisition strategies and optimized experimental conditions

Advancing Solid-State Understanding in Drug Development

Solid-state NMR (ssNMR) plays a critical role in pharmaceutical development by providing detailed structural and dynamic insights that support solid-form selection, formulation development, and product stability assessment.

From early-stage characterization through commercial development, ssNMR enables informed decision-making and reduces solid-state risks across the drug development lifecycle.

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Our capabilities span three specialized platforms:

Small Molecule
Crystal Bio Solutions
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