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Automated In-Vitro Testing

Automate Your PhysChem Benchwork to De-Risk Your API

Better datasets for better decisions early in development


There is a new standard for measuring the physicochemical properties of your drug earlier in the development timeline to prevent backwards and inefficient decisions on your way to in vivo and FIH studies.

At early stages of drug development, a limited supply of API historically made it a challenge to gather sufficient data to guide candidate selection in vivo studies. 

This resulted in:

A Novel Path to Sprint from Molecule to Medicine

Earlier than ever before in the development timeline, biotechs can achieve a comprehensive understanding of their molecule's physicochemical properties. Using material-sparing automation, Crystal Pharmatech guides their partners towards smarter decisions before more time and money is invested in their development process.

If your API benchwork is not utilizing advanced automation, 

you are wasting API and time to receive less accurate results.

Automated and Accurate Measurements of pKa, Log P/D


A thorough understanding of the drug's pKa and Log P, determined through pH and UV metric titration methods, will:


Automated Dissolution and Permeability Determination

Understanding the preliminary metabolism and absorption profile of a compound, is critical to optimize API usage in vivo studies. 

We input biorelevant solubility measurements and predicted permeability into our in silico modelling software. This provides a predicted human PK and guides formulation development.


In volumes as low as 2mL, it is possible to utilize minimal amounts of API to evaluate:

To overcome the challenge of limited API supply, we use Pion's MicroDiss to determine biorelevant dissolution across numerous media and pH ranges. This platform helps us gain a comprehensive understanding of the kinetic solubility of your molecule in different media, which minimizes the amount of animal studies needed to move to FIH.

Benchwork - In Vivo - In Silico - First in Human

Crystal Pharmatech leverages these powerful automations to provide the benchwork needed to run human PK simulations. Our novel path from molecule to medicine provides our biotech partners with a more comprehensive understanding of their molecule to make proactive decisions throughout all stages of development.Pion-Web-Page-Elements-05.jpg


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bd_global@crystalpharmatech.com +1-609-604-8303
Suite 500-B, 3000 Eastpark Blvd, Cranbury, New Jersey 08512, USA
6800 Kitimat Rd, Unit 1, Mississauga, Ontario, Canada L5N 5M1
Suite B4-101, Biobay, 218 Xinghu Street, Suzhou Industrial Park, Suzhou, China, 215123
Suite 500-B, 3000 Eastpark Blvd, Cranbury, New Jersey 08512, USA
bd_global@crystalpharmatech.com +1-609-604-8303