Technical Insight
Solid Form Landscape to Formulation Strategy: The Role of Computational Screening and Risk Assessment
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Evaluation encompasses polymorphs, salts, and co-crystals identified during screening, with a focus on understanding their development potential and associated risks. Over years of technical development, a comprehensive evaluation framework has been established to support robust decision-making.
Advanced characterization techniques, including XRPD, DSC, TGA, DVS, and particle size analysis, are used to evaluate thermodynamic and kinetic stability, transformation pathways, solubility, hygroscopicity, and flow properties.
Particle attributes, processability, excipient compatibility, formulation stability, and dissolution performance are evaluated to ensure suitability for formulation development. These data directly support solid form selection and formulation strategy.
_420236.webp "Solid Form Landscape to Formulation Strategy: The Role of Computational Screening and Risk Assessment")
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