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Review of Polymorph Patent Application of 30 Small Molecule New Drugs Approved by the FDA in 2023
26 Feb 2024
Review of Polymorph Patent Application of 30 Small Molecule New Drugs Approved by the FDA in 2023
In 2023, the FDA's Center for Drug Evaluation and Research (CDER) approved a total of 55 new drugs, which included 38 new molecular entities, of which 30 were small molecule drugs. In terms of adm...
Development and Production Application Cases of Amorphous Solid Dispersion Formulations (II) - Spray Drying
30 Jan 2024
Development and Production Application Cases of Amorphous Solid Dispersion Formulations (II) - Spray Drying
In the preceding article, we discussed the application of hot-melt extrusion technology in developing amorphous solid dispersions (ASD) for pharmaceutical formulations. The process involves dispersing...
Development and Production Application Cases of Amorphous Solid Dispersion Formulations (I) - Hot Melt Extrusion
10 Jan 2024
Development and Production Application Cases of Amorphous Solid Dispersion Formulations (I) - Hot Melt Extrusion
Hot-melt extrusion (HME) is recognized as an optimal and efficient technique for manufacturing amorphous solid dispersions, characterized by its continuous processing, increased production efficiency,...
Understand ASD Manufacturing Strategies, Choose the Optimal One
14 Dec 2023
Understand ASD Manufacturing Strategies, Choose the Optimal One
Preparation Method of Amorphous Solid DispersionsAlthough various techniques are currently available for preparing amorphous solid dispersions (ASD), the fundamental principles governing their formati...
A Brief Introduction to Amorphous Solid Dispersion Technology
05 Dec 2023
A Brief Introduction to Amorphous Solid Dispersion Technology
The swift advancements in pharmaceutical technology are consistently leading to significant breakthroughs in the realm of small molecule development. In this scenario, pharmaceutical formulations are ...
Unlock Solubility Enhancement Methods for Poorly Soluble Oral Drugs
04 Dec 2023
Unlock Solubility Enhancement Methods for Poorly Soluble Oral Drugs
Oral solid drugs are widely used in the pharmaceutical industry due to good stability, cost-effectiveness, and convenient portability and administration. Oral drug absorption relies on dissolution as ...
Applications of Dynamic Moisture Adsorption in Crystal Research
22 Nov 2023
Applications of Dynamic Moisture Adsorption in Crystal Research
Content Overview1. Introduction2. Regulatory Requirements3. Application of Dynamic Vapor Sorption (DVS)3.1 Instrument Introduction3.2 Application 1 - Moisture Sorption Assessment3.3 Application 2 - Va...
Shining Glory: Unveiling the "True Eye" behind the Veil of Drug Crystal Forms
15 Nov 2023
Shining Glory: Unveiling the "True Eye" behind the Veil of Drug Crystal Forms
Are you still troubled by the characterization of solid state?How to determine whether the prepared crystal form is the same?Compounds have polymorphism. Is it necessary to conduct impurity crystal fo...
Application of Granularity Analysis in Crystal Typing Research
08 Nov 2023
Application of Granularity Analysis in Crystal Typing Research
This article series is initiated and compiled by the Crystalline Cloud Solid-State Testing Center. Its aim is to create a platform for exchange and learning among industry peers. We intend to explore ...
Polymorphs, Solvatomorphs and Hydrate of Dabrafenib
01 Nov 2023
Polymorphs, Solvatomorphs and Hydrate of Dabrafenib
The solid-form screening and selection of active pharmaceutical ingredients (API) are crucial steps in the process of process development.
Amorphous Solid Dispersion Technology and the Service Advantages of Crystal Pharmaceutical
16 Oct 2023
Amorphous Solid Dispersion Technology and the Service Advantages of Crystal Pharmaceutical
With the rapid development of biopharmaceutical technology, the field of small molecule drug discovery continues to achieve significant breakthroughs. In this context, pharmaceutical formulations play...
Development and Production Application Case Study of Amorphous Solid Dispersions: Spray Drying
12 Oct 2023
Development and Production Application Case Study of Amorphous Solid Dispersions: Spray Drying
In the previous article, we introduced the application of hot-melt extrusion technology in the development of amorphous solid dispersions in pharmaceutical formulation. Spray drying (SD) is another co...
Case Study on Development and Production Applications of Amorphous Solid Dispersions - Hot Melt Extrusion
08 Oct 2023
Case Study on Development and Production Applications of Amorphous Solid Dispersions - Hot Melt Extrusion
Hot melt extrusion (HME) is a common formulation technology for amorphous solid dispersions (ASD) with advantages such as continuity, high production efficiency, low energy consumption, and environmen...
ASD Column | How to Select Polymers in Hot-melt Extrusion Process?
07 Oct 2023
ASD Column | How to Select Polymers in Hot-melt Extrusion Process?
Hot melt extrusion (HME) technology is widely used in the development of amorphous solid dispersions (ASD) due to its advantages such as solvent-free processing, continuous manufacturing, high automat...
ASD Column | Understanding the ASD Preparation Methods and Selecting the Optimal Method for Solution
04 Oct 2023
ASD Column | Understanding the ASD Preparation Methods and Selecting the Optimal Method for Solution
In the previous article "Mastering the Art of Stability," we revealed the key factors influencing the physical stability of amorphous solid dispersions (ASDs) and recognized that choosing th...
ASD Column | Mastering Stable Art: Unveiling Key Factors Influencing Physical Stability of Amorphous Solid Dispersions
01 Oct 2023
ASD Column | Mastering Stable Art: Unveiling Key Factors Influencing Physical Stability of Amorphous Solid Dispersions
/ Formulation Rightthe First Time /In recent years, amorphous solid dispersions (ASD) have attracted attention due to their ability to significantly improve the solubility of poorly soluble drugs. Sin...
Fun Sharing:The Story Between Ice Crystals and Frozen Foods (Part 3)
08 Mar 2023
Fun Sharing:The Story Between Ice Crystals and Frozen Foods (Part 3)
Our sincere suggestion—how to improve the quality of food affected by ice crystals Choose frozen food It is internationally recognized that when the central temperature of frozen food reaches -18℃ r...
Fun Sharing: The Story of Ice Crystals and Frozen Foods (Part 2)
01 Mar 2023
Fun Sharing: The Story of Ice Crystals and Frozen Foods (Part 2)
Ice crystals: Some times I really can't help myself, so let's hear it from me.The influence on food freezing: ice crystal behavior during fast/slow freezing and thawing of foodFor the growth o...
Fun Sharing: The Relationship Between Ice Crystals and Frozen Foods (Part 1)
22 Feb 2023
Fun Sharing: The Relationship Between Ice Crystals and Frozen Foods (Part 1)
Development of Frozen Food It is hard to tell when various brands of frozen dumplings, glutinous rice balls, hand-grabbed pancakes, and frozen meats have filled up the freezer compartment of our refri...
Fun Sharing: The Secret behind the Silky Smooth Enjoyment of Chocolate (Part 3)
15 Feb 2023
Fun Sharing: The Secret behind the Silky Smooth Enjoyment of Chocolate (Part 3)
How to Improve Chocolate ProcessingThe transformation from metastable crystal forms to stable crystal forms is inevitable, it's just a matter of time. Therefore, no piece of chocolate can escape f...
Fun Sharing: The Secret Behind the Silky Smoothness of Chocolate (Part 2)
08 Feb 2023
Fun Sharing: The Secret Behind the Silky Smoothness of Chocolate (Part 2)
The story behind the perfect chocolateThe control of the crystal structure V's nucleation, growth, and stability in the polymorphic system, which is so close and easy to transform each other, has ...
Fun Sharing: The Secret Behind the Silkiness of Chocolate (Part 1)
01 Feb 2023
Fun Sharing: The Secret Behind the Silkiness of Chocolate (Part 1)
Origin of Chocolate HistoryFor some reason, chocolate seems to be inherently regarded as a symbol of romance, appearing in literary works and love connections between people. Its unique rich and silky...
Learn about Drug Eutectic Screening
01 Feb 2018
Learn about Drug Eutectic Screening
The selection of solid forms of drugs is an important factor to be considered in the study of drug preparations. The solid form of drugs mainly includes polycrystalline form, salt, hydrate or solvate,...
Crystallization Process Method
01 Jan 2018
Crystallization Process Method
Crystallization is the process by which a substance is precipitated in a crystalline state from a vapor, solution, or molten substance. When drugs crystallize, if different solvents and processes are ...
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