Comprehensive Physicochemical Property Evaluation

The Physicochemical Foundation for Every Downstream Decision

A thorough physicochemical property evaluation is the mandatory starting point for all downstream formulation and process development. Understanding how your API behaves — in solution, in the solid state, and under stress — is essential for rational dosage form selection, formulation design, and the establishment of a robust quality control baseline.

What This Data Enables

01

Druggability evaluation and BCS classification of the compound
02

Rational selection of route of administration and dosage form
03

Informed formulation and process design strategy
04

Identification of physicochemical liabilities early — before significant investment
05

Establishing a baseline for robust analytical method development and quality control

Key Properties We Characterize

Aqueous solubility (thermodynamic and kinetic, pH-dependent)

Intrinsic dissolution rate

pKa (ionization constant) and LogP/LogD (lipophilicity)

Solid-state form identification (XRPD, DSC, TGA, DVS, PLM)

Hygroscopicity and moisture uptake behavior

Chemical and physical stability under stress conditions

Particle size, morphology, and powder flow properties

Melting point and thermal behavior

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Our capabilities span three specialized platforms:

Small Molecule
Crystal Bio Solutions
Crystal NAX

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