Whitepaper
Salts
14 Jul 2022
en
Automated, material-sparing physicochemical analysis for early understanding of molecular ionization and lipophilicity — critical parameters influencing solubility, permeability, and absorption.
Automated pH and UV metric titration enables precise determination of molecular ionization and lipophilicity, providing critical insights for drug development:
Characterize interactions that influence crystal form and solid-state stability.
Generate reliable data that support absorption, distribution, and exposure predictions.
Evaluate solubility behavior across different pH environments to guide design.
Key Physicochemical Parameters
Defines ionization state across physiological pH ranges. Plays a critical role in solubility, salt selection, and formulation strategy.
Describes the partition coefficient between octanol and water. A key indicator for ADME profiling and BCS classification.
Accounts for ionization at specific pH levels. Provides a more accurate predictor of distribution and permeability in physiological environments.
At Crystal Pharmatech, these data integrate directly into our broader Developability Assessment workflow, supporting solid form selection, solubility studies, and PBPK modeling inputs.
By combining automated measurements with advanced in silico modeling using **GastroPlus®**, we deliver a comprehensive understanding at the earliest stages.
Have a question or need support with your project? Please complete the form, and our team will get back to you shortly.
Our capabilities span three specialized platforms:
Small Molecule
Crystal Bio Solutions
Crystal NAX
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