Technical Insight
Solid Form Landscape to Formulation Strategy: The role of computational screening and risk assessment
Polymorphs sit at the intersection of chemistry, formulation, and long-term risk. Traditional solid-form screening gives real, valuable data, but it is never exhaustive. By combining those experimental efforts with in-silico predictions, teams can see where they are on the solid-form energy landscape, estimate the impact of unseen forms, and make clearer decisions on screening, formulation, and backup plans.