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Focus on PROTAC Compounds: Development Strategy

Proteolysis-targeting chimeras (PROTACs) degrade proteins, expanding therapeutic reach to undruggable targets while offering selectivity and efficacy. Their poor solubility, high polarity, and large size hinder bioavailability. This article outlines solid-form strategies—polymorph screening and salt/cocrystal optimization—to enhance solubility, stability, and developability in PROTAC drug development.


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Small Molecule
Mol2Med™ Integrated Services Developability Assessment API Form and Solid-State Research Crystallization Development Services Pre-formulation Studies Formulation and Analytical Development GMP Manufacturing Clinical Supply
Crystal Bio Solutions
Biologics CMC Analytical Services Bioanalytical and Biomarker Services Quantitative Clinical Pharmacology (QCP)
Technology
Quick Links
About Us Events
NJ Sites: Suite 500-B, 3000 Eastpark Blvd, Cranbury, New Jersey, USA 08512
2005 Eastpark Blvd, Cranbury, New Jersey, USA 08512
CA Site: 7133 Koll Center Parkway, Suite 200, Pleasanton, California, USA 94566
bd_global@crystalpharmatech.com +1-609-604-8303
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