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Solid Form Screening and Selection Solid form is a general term that refers to both crystalline and amorphous materials. The solid form will impact active pharmaceutical ingredient (API) development properties such as solubility, dissolution rate, stability, hygroscopicity, and bioavailability.
First-Time-Right 3-STEP Approach Crystal Pharmatech are a specialized CRO/CDMO focused on Solid State Research, Pre-Formulation, Formulation Development and Manufacturing. Our strength is our focus and expertise in these specialties...
Bioanalytical and Biomarker Services With more than 100 years of combined industry experience of our leadership team and three GLP compliant laboratories, we are ready for all your current and emerging bioanalytical needs.
Solid-State Characterization/FAST Our Solid State Characterization Service, which is referred to as Focused Analytical Solids Testing (FAST), covers many routine analyses encountered during pharmaceutical development. The FAST concept is directly aligned with our goal of partnering with organizations instead of merely providing data.
Single Crystal Growth & Structure Determination Single crystal growth and structure determination technology are the main methods to determine the absolute configuration of drug molecules and identify the crystal forms absolutely. The single crysta...
pKa/LogP/LogD Measurements Earlier than ever before in the development timeline, biotech can achieve a comprehensive understanding of their molecule's physicochemical properties. Using material-sparing automation, Crystal P...
Quantitative Clinical Pharmacology (QCP)
Crystallization Development The aim of a crystallization process development is to find a crystallization process which can stable produce the optimal solid form with all desired properties such as particle size, particle shape,...
Stability and Solubility Studies Chemical and physical stability. The intent of the stability study is to evaluate the chemical and physical stability of the API in solution and solid-state. The solid-state evaluation will probe the pr...
Comprehensive Physicochemical Property Evaluation A comprehensive physicochemical property evaluation is an important premise for the development of formulation and process. It provides an important basis for the druggability evaluation of the compou...
Chiral Separation More than 70% of drug candidates worldwide are chiral. Typically, for chiral API, only one enantiomer or diasteromer is biologically active or desirable. Therefore, the production of enantiopure compounds or diastereomers is imperative. In the production of small molecule drugs with desired chirality, separation via crystallization can be much more economical and environmentally favorable than chromatography.
In-Silico PBPK Modeling and Simulation Crystal Pharmatech now provides Physiologically Based Pharmacokinetics (PBPK) simulation capability.
Excipient Selection and Compatibility Studies Excipients play an important role in drug release, drug stability and manufacture of drug product. We help customers select the appropriate excipients in early formulation development through screenin...
Flow Cytometry Cell therapy and biomarker (e.g. immunophenotyping and receptor occupancy assays)
Formulations for PK/Efficacy/Tox Studies We adopt integrated approach to find the right form and formulation through our SMART services, leading to the shortest possible development timelines with limited resource utilization.