CPHI North america - Meet Us at Booth #530
Crystal Pharmatech is now more than just your API Form and Solid-State Research Partner. In addition, we can also be your Formulation Development and Innovative Technology Partner. Collectively, Cryst...
Unveil Key Factors Influencing the Physical Stability of Amorphous Solid Dispersions
In recent years, the utilization of Amorphous Solid Dispersions (ASD) has gained increasing interest, particularly for enhancing the solubility of drugs with inherently low solubility. Within ASDs, dr...
Characterization and Evaluation of Amorphous Solid Dispersion (ASD) - Part 1
In previous articles, we have explored prevalent techniques for producing Amorphous Solid Dispersion (ASD), such as spray drying and hot melt extrusion, highlighting their respective benefits, limitat...
Meet Crystal Pharmatech at AAPS National Biotechnology Conference
Crystal Bio's CSO, Billy Wu, Ph.D. will be in San Francisco with Crystal Pharmatech's BD Director, Chris Heard, for the American Association of Pharmaceutical Scientists (AAPS) | @aapscomms Na...
Optimizing Polymer Selection for Amorphous Solid Dispersion in Hot Melt Extrusion Processes
Hot melt extrusion (HME) technology is widely used in the development of amorphous solid dispersions, offering advantages such as a solvent-free preparation process, continuous operation, high automat...
Crystal's Perspective: Polymorph Patent Landscape of 28 FDA-Approved Small Molecule Drugs in 2024
Crystal’s Perspective: Polymorph Patent Landscape of 28 FDA-Approved Small Molecule Drugs in 2024 In 2024, the U.S. Food and Drug Administration (FDA) approved a total of 50 new drugs [1], including ...
.webp "How to Mitigate Disproportionation of API Salts in Pharmaceutical Formulations")
How to Mitigate Disproportionation of API Salts in Pharmaceutical Formulations
Salt formation is a well-established strategy for improving the physicochemical properties of active pharmaceutical ingredients (APIs) containing ionizable groups. This approach is particularly effect...
Focus on PROTAC Compounds: Development Strategy
This series looks at the physicochemical challenges of PROTAC compounds. It explains how polymorph screening, salt/cocrystal optimization, and formulation and dosage-form development can improve solub...
.webp "Enhancing Drug Product Performance Through Spray Drying Parameter Optimization")
Enhancing Drug Product Performance Through Spray Drying Parameter Optimization
As amorphous solid dispersions (ASDs) and their formulations advance from lab-scale research to clinical trials and, ultimately, to commercial production, manufacturing scales increase from grams to k...
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