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Parameter Sensitivity with GastroPlus

How can physiologically-based pharmacokinetic (PBPK) modeling maximize ADME performance and identify a path forward for GLP Tox and FIH formulations?

GastroPlus incorporates in-vivo and in-vitro data to build animal models. The animal models can be scaled to human models, providing advanced insights on ADME performance in animals and humans.

Case studies on insights that drive more efficient development…


  



 

 

 

 

 


 

 


GastroPlus parameter sensitivity offers a more efficient alternative to trial-and-error PK studies as drug innovators look to rapidly determine the effects of various parameters on bioavailability.


These early insights, combined with experienced solid-state chemists and formulators, can provide invaluable insights for lead candidate selection and the optimal GLP Tox and FIH formulation approaches.


Crystal Pharmatech has in-house experts in GastroPlus PBPK modeling and regularly helps innovators incorporate PBPK modeling into their programs for more efficient and effective development.


If you would like to learn more about how this powerful tool can benefit your program, please reach out to BD_Global@CrystalPharmatech.com.


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Suite 500-B, 3000 Eastpark Blvd, Cranbury, New Jersey 08512, USA
bd_global@crystalpharmatech.com +1-609-604-8303